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Significance Human blood dendritic cells (DCs) are composed of different subsets endowed with specific and complementary functions in the course of an immune response against pathogens such as viruses. A new population of circulating precursors of DCs (pre-DCs) has been recently identified by high-dimensional approaches. Besides their role in DC ontogeny, pre-DCs remained uncharacterized upon pathogen encounter. Here we show that their constitutive expression of Siglec-1, a receptor known to bind HIV-1 particles, confers them with a unique set of properties with regards to HIV-1, including viral capture, infection, and transfer. Thus, circulating pre-DCs may contribute to the antiviral immune response by providing a source of viral antigens to other DC populations.

Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursors