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Significance Abortive viral infections are defined as cells that have been infected with a virus but did not produce any progeny virus as a result of the infection. Recent single-cell studies have shown that abortive infection is observed frequently even during infection of susceptible and permissive cell types. Here, we recovered populations of susceptible and permissive cells that survived infection with herpes simplex virus at high multiplicity of infection. We found that these abortive cells maintain viral genomes in a quiescent state at least for 5 wk. These viral genomes can reactivate to produce new progeny viruses. These findings suggest that abortive HSV-1 infection leads to spontaneous latency-like infection in nonneuronal cells, challenging the current paradigm of herpesviruses latency.

Abortive herpes simplex virus infection of nonneuronal cells results in quiescent viral genomes that can reactivate