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Significance The virus bacteriophage T4 infects the bacteriumEscherichia coli using an intriguing nanoscale injection machinery that employs a contractile tail. The injection machinery is responsible for recognizing and puncturing the bacterial host and transferring the viral genome into the host during infection. Fundamental questions remain concerning how this injection process unfolds in real time, a process that presently defies direct experimental observation. Using a combination of atomistic and continuum representations, this study contributes a system-level model of the entire bacteriophage T4 interacting with a host cell, and in doing so, it exposes the energetics, forces, and dynamical pathway associated with the injection process. The results have further implications for future nanotechnology devices for DNA transfection and experimental phage therapies.

How the phage T4 injection machinery works including energetics, forces, and dynamic pathway