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Significance Hair cells of the cochlea transduce mechanical energy into electrical signals. Acoustic stimulation of mechanotransduction channels generates a graded receptor potential that elicits glutamate release from hair cells onto postsynaptic auditory nerve fibers. The amplitude and time course of the receptor potential is shaped by activation of Ca2+ - and voltage-dependent K+ channels (BK channels). Hair cell BK channels are unusual in that, even in the absence of Ca2+ , they are activated at more negative potentials than any other known BK channel. Here we show that a specific regulatory gamma subunit, LRRC52, is a key determinant in inner hair cells of the negative activation range of BK channels. Furthermore, the absence of LRRC52 disrupts BK channel clustering and localization.

LRRC52 regulates BK channel function and localization in mouse cochlear inner hair cells