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Significance Although exposure to fine particulate matter (PM) during pregnancy is linked to high risks of adverse pregnancy outcomes and long-term postnatal health, limited mechanistic data exist to assess these impacts under controlled exposure conditions. Here we show that maternal exposure to ultrafine ammonium sulfate aerosols impacts prenatal and postnatal organogenesis in offspring and predisposes metabolic syndrome in adult life. Our animal model reveals increased stillbirths; reduced gestation length and birth weight; increased concentrations of glucose and free fatty acids in plasma; enhanced lipid accumulation in the liver; and decreased endothelium-dependent relaxation of aorta. Understanding the impacts and elucidating the underlying mechanisms for maternal PM exposure are essential in developing strategies to reduce adverse health effects on conceptus/postnatal growth and development.

Adverse organogenesis and predisposed long-term metabolic syndrome from prenatal exposure to fine particulate matter