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Significance Action potential-mediated neurotransmission is essential in the nervous system. Ca2+ is established for its key role in vesicular exocytosis. We previously reported a type of somatic exocytosis triggered by the action potential per se—Ca2+ -independent but voltage-dependent secretion (CiVDS)—in primary sensory neurons and recently revealed its molecular mechanism. By using cutting-edge methods, here we show that CiVDS exists in the sympathetic nervous system and may play an important role in the cardiovascular system in mammalians, including rodents and humans. These findings generalize CiVDS from a sensory neuron to the sympathetic nervous system that projects to all essential organs.

Ca2+-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian sympathetic nervous system

Ca²⁺-independent but voltage-dependent quantal catecholamine secretion (CiVDS) in the mammalian sympathetic nervous system