English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Significance Claudin is the core protein making the tight junction and the paracellular channel. Whether it may regulate the transcellular pathway is not known. Here, we have discovered that phosphorylated claudin-16 proteins are not localized in the tight junction but found in the luminal membrane of the distal tubular cells, where they facilitate the transcellular Ca++ permeation via Trpv5. This discovery not only resolves a longstanding mystery pertaining to the role of transcellular Ca++ pathway in the FHHNC syndrome, but also reveals a class of functional binding partners for Trp channels.

Phosphorylated claudin-16 interacts with Trpv5 and regulates transcellular calcium transport in the kidney