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Significance Mechanosensory cells convert environmental mechanical stimuli into intracellular signals. This process, termed mechanotransduction, occurs in specialized mechanoreceptive organelles. Using electron tomography we discovered that the mechanoreceptive organelle in fly campaniform mechanoreceptors contains thousands of force-sensitive ion channels that are arranged in a regular pattern, aligned to the intracellular microtubule cytoskeleton. A mechanical model suggests that the pattern is structurally and functionally optimized, because more force-sensitive channels are located at regions that are subject to larger activating forces. We propose that such a pattern enhances the sensitivity and broadens the dynamic range of mechanosensation in this type of mechanoreceptor.

Ultrastructural organization of NompC in the mechanoreceptive organelle of Drosophila campaniform mechanoreceptors