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Significance TheArabidopsis R2R3-MYB transcription factor FOUR LIPS (FLP) is the first identified key transcription factor regulating stomatal development. By screening and analyzing a genetic suppressor offlp stomatal defects, we found thatFSP1/RPA2a , which encodes a core subunit of Replication Protein A (RPA) complexes, acts downstream of B1-type Cyclin-Dependent Kinases (CDKB1s). This ensures that terminal division during stomatal development will produce a pair of kidney-shaped guard cells to compose a functional stomatal complex. We demonstrate that the CDK-mediated phosphorylation at the N terminus of RPA2a is essential for the RPA functions in cell cycle control and response to DNA damage. We provide direct evidence for the existence of an evolutionarily conserved, but plant-specific, RPA regulatory pathway in plants.

A conserved but plant-specific CDK-mediated regulation of DNA replication protein A2 in the precise control of stomatal terminal division