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Significance Posttraumatic stress disorder (PTSD) is an important risk factor for suicidal ideation, attempts, and death by suicide. Understanding of the biology underlying suicidality in PTSD is limited. In this study, we used positron emission tomography to evaluate the metabotropic glutamate receptor type 5 (mGluR5) as a potential treatment target and biomarker of suicidal ideation in individuals with PTSD and major depressive disorder (MDD). We found higher availability of mGluR5 in individuals with PTSD relative to healthy control and MDD groups. Furthermore, higher mGluR5 availability was associated with scan-day suicidal ideation among individuals with PTSD, but not MDD. Findings identify mGluR5 as a biomarker for intervention and potentially suicide risk management in PTSD.

In vivo evidence for dysregulation of mGluR5 as a biomarker of suicidal ideation