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Significance One theory of cerebellar function proposes that it creates internal models for action planning, timing, and sensory processing. Purkinje neurons in the caudal vermis of macaques carry a model of gravitational and linear acceleration, and here we show that this computation is evolutionarily conserved and represented across multiple lobules of the rodent vermis. Further, we show that genetically blocking Purkinje neuron GABAergic output leaves this computational ability intact, but leads to increased response modulation amplitude. We conclude that Purkinje neuron feedback regulates gain control within the cerebellar circuit.

Genetically eliminating Purkinje neuron GABAergic neurotransmission increases their response gain to vestibular motion