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Significance Serum IgG, which is mainly generated from IgG-secreting plasma cells in the bone marrow (BM), protects our body against various pathogens. We show here that the protein SiiE ofSalmonella is required to prevent an efficient humoral immune response against the pathogen by selectively reducing the number of IgG-secreting plasma cells in the BM. Attenuated SiiE-deficientSalmonella induces high titers of specificSalmonella -specific IgG and qualifies as an efficient vaccine againstSalmonella . A SiiE-derived peptide with homology to laminin β1 is sufficient to ablate IgG-secreting plasma cells from the BM, identifying laminin β1 as a component of niches for IgG-secreting plasma cells in the BM.

Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG + plasma cell persistence in the bone marrow

Salmonella SiiE prevents an efficient humoral immune memory by interfering with IgG ⁺ plasma cell persistence in the bone marrow