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Significance Rapid graft revascularization, while critical for graft survival, is often not seen in current grafts due to poor basal vascularization. In the present work, we assessed the effect of engineered vessel network assembly and maturation in pre-vascularized constructs prior to implantation on the dynamics of graft integration and perfusion. Grafts bearing highly complex and mature vessel networks were rapidly invaded by host vasculature, which anastomosed with the engineered vessels, promoting their perfusion and reducing blood clot accumulation in the graft. The implantation of grafts with highly mature engineered vessels promises to improve graft integration with the host vasculature and its overall survival.

Mature vessel networks in engineered tissue promote graft–host anastomosis and prevent graft thrombosis