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Significance Promoting effective CD8+ T cell memory is a primary goal of T cell-based vaccination and immunotherapy strategies. While it is well established that CD4+ T cell help is required for enduring CD8+ T cell memory, how such help contributes to establishing optimal CD8+ T cell memory generation and persistence remains unclear. In this study, we demonstrate that CD4+ help at the time of priming ensures that memory CD8+ T cells are programmed to engage metabolic biological pathways essential for effective recall responses. Such understanding has clear implications for the augmentation of vaccine therapies designed to promote protective T cell immunity.

CD4+T help promotes influenza virus-specific CD8+T cell memory by limiting metabolic dysfunction

CD4⁺T help promotes influenza virus-specific CD8⁺T cell memory by limiting metabolic dysfunction