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Significance Defensins are antimicrobial peptides exhibiting antibacterial, antifungal, and antiviral activity. They are expressed by epithelial cells at the intestinal mucosal surface where they play a crucial role in the host intestinal homeostasis. Therefore, approaches aiming to boost their expression represent a promising therapeutic strategy to treat infections and dysbiosis-driven diseases in humans at a time of increasing incidence of antibiotic resistance.

Natural molecules induce and synergize to boost expression of the human antimicrobial peptide β-defensin-3