English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Heart failure is the leading cause of death worldwide. Cardiac regeneration studies currently focus on zebrafish, urodeles, and mammals, bypassing the amphibianXenopus laevis , despite being considered as a leading model for regeneration research. We thus took advantage ofX. laevis as a model to explore thyroid hormone (TH) influence on the cardiac regenerative process. We suggest a possible link between altered TH availability and the loss of cardiac regenerative capacity. Examining heart regeneration inXenopus provides insight into how TH levels may contribute to the enigmatic loss of cardiac regeneration during vertebrate development, suggesting potential therapeutic leads of major biomedical and fundamental relevance for the development of future regenerative strategies, and ultimately to provide therapies for the human heart.

Stage-dependent cardiac regeneration inXenopusis regulated by thyroid hormone availability