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Significance A principal component of the nerve cell is its cytoskeleton—a network of actin, tubulin, and intermediate filament polymers that maintains cell structure, directs cell growth, and transport of cargo. Here, we show that intermediate filaments can alter the dynamics of microtubules to affect developmental synapse remodeling inCaenorhabditis elegans . Accumulation of intermediate filaments is concurrent with hyperstablization of microtubules, which in turn prevents synaptic vesicle transport during rewiring. Our results identify a regulatory role for intermediate filaments in neurons in vivo, providing insight into the mechanisms behind neurological disorders such as ALS, where patients often present with accumulations of intermediate filaments in dying nerve cells.

Intermediate filament accumulation can stabilize microtubules in Caenorhabditis elegans motor neurons