English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Significance Reading of the genetic code is an intricate process in which the ribosome plays an active role in ensuring that translation proceeds rapidly and accurately. Studies have revealed that the mRNA adopts an unusual structure between the P and A sites of the small ribosomal subunit, where it is significantly kinked. In this work we probed the role of the kink structure in decoding. Substitutions that disrupt this structure were found to increase the accuracy of decoding. Conversely, peptide-bond formation on difficult-to-decode codons was severely reduced when this kink structure was perturbed. Our data suggest that the rigid nature of the mRNA backbone is important for ensuring efficient codon–anticodon interactions under suboptimal conditions.

Decoding on the ribosome depends on the structure of the mRNA phosphodiester backbone