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Significance Success or failure of CD8+ T cell responses dictates whether an infected patient can control HIV durably. HIV-specific CD8+ T cells from HIV controllers and chronic progressors were shown to differ in their antiviral function. Here, we investigated whether HIV-specific T cell receptors (TCRs) can explain functional differences in CD8+ T cells from patients with differential immunologic control. Through in vitro, in vivo, and in silico studies, we found that HIV-specific TCRs were functionally equivalent. These results suggest that the factors that modulate the CD8+ T cell response to HIV are independent of their TCRs.

T cell receptors for the HIV KK10 epitope from patients with differential immunologic control are functionally indistinguishable