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Vascular endothelial growth factor (VEGF) family members and their receptors have long been considered suitable anticancer targets (1) because of their role in angiogenesis. Although their full potential remains to be realized, two monoclonal antibodies have been Food and Drug Administration-approved against human cancer: bevacizumab (humanized anti-VEGFA) and ramucirumab (fully human anti-VEGFR2). In PNAS, Wentink et al. (2) describe the rational engineering of 3D-structured peptides that mimic the bevacizumab binding site of VEGFA, thereby eliciting a strong immunogenic response in rats. The resulting sera proved at least as efficient as bevacizumab itself in inhibiting tumor xenografts in immunodeficient mice. Active immunization of immunocompetent mice bearing syngeneic …

An antivascular vaccine to boost self-immunity and strike the tumor