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Significance Nonalcoholic fatty liver disease (NAFLD) is a common chronic hepatic disease, eventually leading to liver fibrosis and cirrhosis. Currently, no effective treatment is available. This study reports the role of cytochrome P450 omega-hydroxylase 4A14 (CYP4A14) in the development and progression of NAFLD. Overexpression of CYP4A14 promotes, whereas gene disruption of CYP4A14 attenuates, high-fat diet (HFD)- and methionine and choline-deficient diet (MCD)-induced liver lipid accumulation. Ablation of CYP4A14 gene markedly attenuates liver damage, inflammation, and fibrosis in MCD-induced nonalcoholic steatohepatitis (NASH). CYP4A14 may represent a therapeutic target for the treatment of NAFLD.

Ablation of cytochrome P450 omega-hydroxylase 4A14 gene attenuates hepatic steatosis and fibrosis