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Significance Bcc bacteria are intrinsically resistant to multiple antibiotics. They are major pathogens in patients with cystic fibrosis (CF) and can cause severe necrotizing pneumonia, which is often fatal. Hopanoid biosynthesis is one of the major mechanisms involved in multiple antimicrobial resistance of Bcc pathogens. ThehpnN gene ofB. multivorans encodes an integral membrane protein of the HpnN family of transporters, which is responsible for shuttling hopanoids to the outer membrane. Here, we report crystal structures ofB. multivorans HpnN that indicate a plausible pathway for hopanoid transport. Overall our data suggest a novel mechanism for hopanoid transport involved in cell wall remodeling, which is critical for mediating multidrug resistance inBurkholderia .

Crystal structures of the Burkholderia multivorans hopanoid transporter HpnN