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Significance Injured tissues can self-heal. The healing process requires that tissue first migrate into the injury site and, upon collision with other expanding tissue fronts, switch from migration to cell–cell adhesion to seal the injury mechanically. The minimum signal inducing this switch is unknown due to the complexity of natural healing interfaces. We made a 3D barrier that mimicked the edge of a tissue and induced healing tissues to collide with it. When we coated the barrier with E-cadherin, a key cell–cell adhesion protein, epithelial tissues behaved as if the barrier were a tissue and stably healed against the barrier. This work reveals a key role for E-cadherin in self-healing, and an alternate way to integrate objects into tissue.

Epithelial self-healing is recapitulated by a 3D biomimetic E-cadherin junction