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Significance Chromosome segregation errors during female meiosis, the leading cause of birth defects and miscarriages, increase dramatically as women age. Because oxidative damage increases with age and oocytes age during a woman’s lifetime, one factor that may contribute to increased segregation errors in older women is damage of the protein linkages (cohesion) required for accurate segregation. In support of this hypothesis, we find that inducing oxidative stress inDrosophila oocytes during meiotic prophase causes a significant increase in segregation errors due to premature loss of cohesion. These data demonstrate that oxidative stress during the stage at which human oocytes remain arrested for decades can cause meiotic segregation errors and offer insight into why cohesion deteriorates with age.

Oxidative stress in oocytes during midprophase induces premature loss of cohesion and chromosome segregation errors