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Significance The main significance of these long-term studies lies in establishing chicken Rous sarcoma virus (RSV) genome integration into a rodent species cell genome in the absence of infectious virus production. Infectious virus, however, can be rescued by fusion of RSV-transformed rodent cells with permissive chicken fibroblasts, which provide some functions critical for full virus expression. The nature of chicken factors required and the role of viral envelope changes are discussed.

On board a raft or boat in the retrovirus sea