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Significance Distinct membranes separate cellular organelles, and communication between organelles occurs primarily at the interorganelle membrane junctions, which are established by junctional proteins. The junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) are essential for lipid transfer and Ca2+ dynamics; however, little is known about the composition of these junctions in T cells. We identified a protein complex containing junctophilin-4 and junctate as components of the ER–PM junctions that regulate Ca2+ dynamics in T cells by interacting with stromal interaction molecule 1 (STIM1), an essential activator of store-operated Ca2+ channels. This study highlights an important role of junctional proteins in T cells and helps in uncovering the pathological mechanisms underlying human diseases due to mutations in these proteins.

Junctophilin-4, a component of the endoplasmic reticulum–plasma membrane junctions, regulates Ca 2+ dynamics in T cells

Junctophilin-4, a component of the endoplasmic reticulum–plasma membrane junctions, regulates Ca ²⁺ dynamics in T cells