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Significance Mounting epidemiological and genetic evidence suggests that the disruption of circadian rhythms is at the origin of pathologies. It is known that people who are engaged in shift work and exhibit a shifted feeding schedule often develop a cohort of metabolic pathologies including diabetes, obesity, and metabolic syndrome. However, the molecular mechanisms that are at the origin of these pathologies are poorly understood. Using mice, we now revealed at the molecular level how metabolic alterations generated on shifting the eating schedule from the normal active phase to the rest phase creates a misalignment’ between the central and peripheral circadian clocks. Importantly, we demonstrate that this misalignment progressively induces a metabolic pathological syndrome similar to that observed in shift workers.

Shifting eating to the circadian rest phase misaligns the peripheral clocks with the master SCN clock and leads to a metabolic syndrome