English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Plus monthly

Global: Zendy Tools annual

Global: Zendy Tools monthly

Global: Zendy Free Plan

Significance Several immunotherapies are approved for treating cancer patients, including aCTLA-4 (anti–cytotoxic T-lymphocyte–associated protein 4; ipilimumab) and anti–PD-1 (anti-programmed cell death protein 1; nivolumab; pembrolizumab), but the best clinical results are coming from combination immunotherapy. Our research demonstrates that aOX40 (anti-CD134)/aCTLA-4 immunotherapy can lead to a potentially tumor-promoting Th2-cytokine milieu (IL-4, IL-5, IL-13) when relying on endogenous antigen presentation. However, aOX40/aCTLA-4 treatment combined with a tumor antigen-specific vaccine, DEC-205 (anti–dendritic and epithelial cells, 205 kDa)–HER2 (human epidermal growth factor receptor 2), promoted robust tumor infiltration by effector CD8 T cells and restored Th1 polarization of CD4 T cells, leading to improved overall survival in a mammary carcinoma model. This study has direct relevance for the design of combination therapy trials in patients.

Combination OX40 agonism/CTLA-4 blockade with HER2 vaccination reverses T-cell anergy and promotes survival in tumor-bearing mice