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We thank Backes and Keller (1) for their comments on our recent publication (2). With regard to the first example in their cluster analysis point, it is great to see that Backes and Keller (1) uncovered more clusters among our reported data, as this provides further support for the nonaccidental nature of these molecules. With regard to the second example, where they did not find a direct overlap, it is indeed because of variations in individual samples, as Backes and Keller already speculated; there are a handful of …

Reply to Backes and Keller: Identification of novel tissue-specific and primate-specific human microRNAs