English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

We appreciate the comments of van de Sandt and Rimmelzwaan (1) on our paper (2), as well as the opportunity to respond. First, we agree that in Berkhoff et al. (3) single alanine replacements resulted in reduced kinetics of viral replication. Nonetheless, to claim “a reduction of progeny virus of >90%” (1) for all substitutions is misleading. Although figure 1A of Berkhoff et al. shows this at one unspecified time after Madin-Darby canine kidney infection, figure 1 B and D of Berkhoff et al., plotting viral titers as a function of time, reveals far less reduction (3). The latter may be more relevant for physiologic infection, where immune mechanisms limit …

Reply to van de Sandt and Rimmelzwaan: Matching epitope display with functional avidity