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Significance Noninvasive tracking of T cells is an important method to reveal basic mechanisms of T-cell–based immunotherapies. Herein, to our knowledge we show for the first time that intracellular labeling of mouse lymphocytes for in vivo PET can be achieved by targeting membranous T-cell receptors with specific64 Cu-coupled antibodies because of a continuous plasma membrane turnover. This direct-labeling method provides impressive advantages compared with common radioactive labeling methods, like [64 Cu]PTSM or [111 In]oxin, with regard to minimized influences on the target cells, while providing a high labeling stability and contrast. Thus, in noninvasive in vivo cell-tracking PET studies, we could follow the specific homing of T cells into inflamed tissues. Consequently, this method is easily transferable to other immune cell populations.

64 Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET

⁶⁴ Cu antibody-targeting of the T-cell receptor and subsequent internalization enables in vivo tracking of lymphocytes by PET