English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Polycyclic aromatic hydrocarbons (PAHs) constitute a class of well-characterized environmental pollutants. Benzo[a ]pyrene (BP), a typical and extensively studied PAH, can be metabolically converted to mutagenic reactive intermediates in vivo to form the major 10S (+)-trans -anti -BP diol epoxide (BPDE)-N 2 -dG (BPDE-dG) lesions and thus impede DNA replication and enhance mutagenesis. DNA polymerase κ (Polκ) is the only known DNA polymerase in mouse or human cells that can bypass the BPDE-dG adduct in an error free manner, thereby reducing mutation risk. Here we show that a structural gap and the N-clasp of Polκ are essential for accurate translesion synthesis of the bulky adduct.

Variants of mouse DNA polymerase κ reveal a mechanism of efficient and accurate translesion synthesis past a benzo[ a ]pyrene dG adduct