English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Peripheral neuropathies are a group of disorders affecting peripheral nerves, characterized by either distal axonal degeneration or dysfunction of the ensheathing Schwann cells. Depending on the type of peripheral nerve involvement, there are many different symptoms and examination findings in patients with peripheral neuropathy. However, neuropathic pain is probably the single most prevalent complaint that results in consultation with a doctor. Although symptomatic therapies exist for treating pain in peripheral neuropathies (1), none are very effective or specific to the underlying pathogenic mechanisms, often resulting in too many side effects. There is a desperate need in the field to develop pathogenesis-based specific treatments to treat painful symptoms in patients with peripheral neuropathies. In PNAS, Hedstrom et al. present convincing preclinical data to show that enhancement of glial cell-line derived neurotrophic factor (GDNF) signaling with a small molecule agonist offers such a hope (2). Exact pathogenic mechanism(s) of neuropathic pain are still unknown. The complexity of neuropathic pain is exemplified with the recognition that in a given patient various painful symptoms may have different underlying pathogenic mechanisms, and over time, even for the same type of pain, the underlying molecular mechanism may change. This is partly due to the fact that sensory organs in the skin often encode multiple types of sensations and that a single type of stimulus such as heat may require multiple transduction pathways (3 …

Augmenting glial cell-line derived neurotrophic factor signaling to treat painful neuropathies