English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Significance Antigen-specific therapies are lacking for autoimmunity diseases. The recent discovery of the nature of the IAg7 –insulin complex that drives type 1 diabetes in nonobese diabetic (NOD) mice has allowed us to create a monoclonal antibody specific for this complex. This antibody delays diabetes development in NOD mice. Given the similarities between IAg7 and the human diabetes risk alleles, HLA-DQ2 and HLA-DQ8, this work encourages the development of similar monoclonal antibodies for the treatment of the human disease.

Monoclonal antibody blocking the recognition of an insulin peptide–MHC complex modulates type 1 diabetes