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Significance HIV-1 infection and the associated disease AIDS are a major cause of human death worldwide with no vaccine or cure available. The assembly of virus particles involves numerous host and viral proteins that are potential therapeutic targets. We used high-resolution microscopy techniques to investigate how the virus hijacks cellular proteins to enable the release of virions from an infected cell. We show with high temporal and spatial resolution that components of the host endosomal sorting complex required for transport (ESCRT) machinery are recruited to the neck of the assembling virus to facilitate scission of the link between the virus and the cell.

Temporal and spatial organization of ESCRT protein recruitment during HIV-1 budding