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Significance Rhythmic clock gene transcription is essential for the functions of eukaryotic circadian clocks. In theNeurospora circadian oscillator, the WHITE COLLAR (WC) complex is responsible for rhythmicfrequency (frq ) transcription and was thought to be the only transcriptional activator forfrq . Here, we show thatfrq can be constitutively transcribed in a WC-independent manner when the transcriptional corepressorrco-1 is deleted. Inrco-1 mutants, high-level constitutive WC-independentfrq transcription results in impaired WC activity and loss of circadian rhythmicity. Our results further indicate that RCO-1 acts together with the histone modifier SET-2 and the chromatin remodeling factor CHD-1 to regulate normal chromatin structure at thefrq locus, which permits rhythmicfrq transcription.

Suppression of WC-independent frequency transcription by RCO-1 is essential for Neurospora circadian clock