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Significance p53 is one of the most highly studied proteins in biomedical research because of its importance in preventing cancer and its direct or indirect role in many biological processes. It is best known as a nuclear protein that is critical for maintaining genomic integrity and regulating gene expression. We have uncovered a molecular mechanism by which p53 translocates into the mitochondria, depending on respiration, and facilitates the repair of oxidative damage to mitochondrial DNA. The dynamic partitioning of p53 between the nuclear and mitochondrial compartments has important implications for cancer and the many other essential functions of p53 in normal physiology.

Mitochondrial disulfide relay mediates translocation of p53 and partitions its subcellular activity