English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

In utero, fetal lung epithelial cells actively secrete chloride (Cl−) ions into the lung airspaces. Cl− ions enter the basolateral membranes through Na+/K+/2Cl− (NKCC) transporters (1), down an electrochemical gradient generated by the basolateral Na+/K+/ATPase, and exit through apical anion channels, including the cAMP- activated cystic fibrosis transmembrane regulator (CFTR) (2). Na+ ions follow passively through the paracellular junctions to preserve electroneutrality. The vectorial transport of NaCl generates an oncotic pressure, which drives fetal fluid secretion into the airway lumen. Shortly before birth, Cl− secretion diminishes and active Na+ transport begins: Na+ ions enter lung epithelial cells through amiloride-sensitive Na+ channels (ENaC) and are extruded across the basolateral membranes by the Na+/K+/ATPase (3, 4). This process is critical for the reabsorption of fetal lung fluid and the establishment of gas exchange. In the adult lung active Na+ reabsorption limits the degree of alveolar edema in hyperoxic lung injury (5) and in patients with acute respiratory distress syndrome (6, 7). In PNAS, Solymosi et al. (8) show that an acute increase of left atrial pressure in isolated perfused rat lungs decreases amiloride-sensitive Na+ reabsorption across alveolar epithelial cells and stimulates Na+ and Cl− uptake through the basolateral NKCC transporter. Decreased Na+ entry through ENaC in epithelial cells also resulted in hyperpolarization of their apical membranes, providing the driving force for …

Chloride secretion across adult alveolar epithelial cells contributes to cardiogenic edema