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Significance The migration of cells during embryo development or in cancer often occurs collectively as a group. Underlying mechanisms have been studied in the zebrafish lateral line, in which Wnt signaling regulates the spatially restricted expression of two chemokine receptors required for directional migration of the cell cluster along the track of Sdf1a ligand. We show that a Hox transcription factor, hoxb8a, is essential for correct migration and acts downstream of Wnt signals to regulate the spatial expression of both chemokine receptors. These findings uncover a Wnt-Hox–chemokine receptor pathway that may act widely in the control of directional cell migration.

A Hox gene controls lateral line cell migration by regulating chemokine receptor expression downstream of Wnt signaling