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Our original article (1) linked exposure of resident killifish to contaminating oil from the Deepwater Horizon (DWH) oil spill with significant biological responses, including genome expression, protein expression, and tissue morphology. Given decades of laboratory studies on the effects of crude oil in many species, including fish, and after extensive field studies following the Exxon Valdez spill, some of the responses we captured are recognized as diagnostic of exposure to, and effects from, the toxic components of weathered crude oil (e.g., ref. 2). Jenkins et …

Reply to Jenkins et al.: Evidence for contaminating oil exposure is closely linked in space and time to biological effects