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The Letter to the Editor by van Vught and colleagues (1) reports a lack of association of the P413L CHGB with ALS susceptibility or age of onset in a Dutch population. This report contrasts with our study that revealed an association of P413L CHGB with ALS susceptibility or age of onset, especially in cohorts from French/French-Canadian origins (2). How to explain these conflicting results? We cannot completely exclude type …

Reply to van Vught et al.: P413L CHGB as risk factor for ALS