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Bouveret syndrome and pancreatic acinar cell carcinoma are two rare conditions of the gastrointestinal tract [1–4]. Herein, we present a case in which both conditions occurred in the same patient. A 77-year-old man with diabetes and a history of cholelithiasis with recurrent episodes of biliary pain was referred for evaluation of epigastric pain, anorexia, nausea, bloating, and weight loss during the previous 6 weeks. Results of laboratory tests were normal. Magnetic resonance imaging demonstrated a solid lesion in the pancreatic head, and the patient was sent for evaluation with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA). Unexpectedly, at the beginning of the procedure, a huge hard gallstone was found to be completely obstructing the pylorus, and was impacted in the first portion of the duodenum. The stone was pulled back into the stomach using a polypectomy snare, and was broken into small fragments with a metal lithotriptor. The small fragments were still too large to be removed via the mouth, as they impacted below the cardia, and were therefore left in the stomach. The patient was asymptomatic, and a small-bowel contrast radiogram some days later confirmed the elimination of the stones. After the removal of the pyloric gallstone, EUS-FNA was performed through de duodenum. A nodule with regular margins and some small cystic areas, measuring 2.4 ×1.8 cm, was found in the head of the pancreas. FNA was performed using a 22-gauge needle, with a total of four passes, and the aspirated material was prepared as cell blocks. Histopathological evaluation and immunohistochemical panel for acinar-specific markers confirmed the diagnosis of an acinar cell carcinoma of the pancreas. Immunohistochemistry was positive for alpha-1-antichymotrypsin, alpha-1-trypsin, and CKM (AE1/AE3/PCK26). In addition, Ki-67 revealed a proliferation index of 70%. VIDEO 1