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Novel coronavirus disease 2019 (COVID-19), sustained by the causative agent called severe acute respiratory syndromecoronavirus-2 (SARS-CoV-2), is highly contagious.1,2 At present, above 2million confirmed cases and over 170,000 deaths of COVID-19 have occurred in the world according to the World Health Organization.3 Pregnant women, because of their special physiological conditions, are susceptible to the virus and put themselves at greater risk.4 Timely control and treatment of pregnant womenwith COVID-19 infection are a major concern.5 Moreover, laboratory medicine plays a vital role in this process.6 Therefore, the purpose of this article is to identify the most common laboratory abnormalities in pregnant women with COVID-19. PubMed, Chinese National Knowledge Infrastructure (CNKI), and Wanfang databases were reviewed by two independent authors, using the keywords “coronavirus” OR “Wuhan coronavirus” OR “SARS-CoV-2” OR “2019 novel coronavirus” OR “2019-nCoV” OR “COVID-19” AND “pregnancy” OR “pregnant woman” OR “pregnant women” OR “vertical transmission” (up to April 20, 2020). There were no country, race, or language restrictions. We included articles reporting laboratory data in pregnant women with confirmed COVID-19 by reading titles, abstracts, and full texts. Besides, the lists of references for all articles were also screened to identify potentially additional articles. A descriptive statistical analysis was applied to summarize their findings. A random-effects model meta-analysis was then carried out to calculate the pooled prevalence and 95% confidence interval (95% CI) to assess the prevalence of laboratory abnormalities in pregnant women with COVID19. Double arcsine method was implemented to make original data conform to normal distribution, and then we analyzed them in software Stata version 11.2 to obtain initial results. Final results were restored by the formula (P1⁄4 [sin (tp/2)]2).7 Begg’s test and Egger’s test were utilized to evaluate publication bias. A total of 244 articles were reviewed, among which 223 were removed due to a lack of laboratory data about pregnant women. Although eight articles reported laboratory data in pregnant women with COVID-19, they were eliminated because of duplicated data. In addition, two articles that did not clearly report laboratory abnormalitieswere also excluded. Overall, a total of 11 articles with 173 pregnant patients were included,8–18 among which 11 women had severe disease, and 2women had critical disease. Most of the patients came from China, and one each came from Korea, the United States, Sweden, Iran, Peru, and Canada. The stages of pregnancy ranged from the first trimester to the third trimester. The characteristics of these patients are indicated in ►Table 1. Four articles were included in the meta-analysis.9,10,15,16 Our results indicated that among all laboratory parameters of pregnant women with COVID-19, the incidence of elevated D-dimer was 82% (95% CI: 75–89%), elevated neutrophil count was 81% (95%CI: 69–91%), elevated C-reactive proteinwas 69% (95% CI: 58–79%), and decreased lymphocyte count was 59% (95% CI: 41–75%). Begg’s test and Egger’s test showed that no publication bias existed (►Table 2). No other laboratory parameters showed apparently consistent changes due to the limitation of available data. Considering the relatively high-sequence identity of SARSCoV-2 and SARS-CoVand the effects of SARS-CoVon pregnant women, wemust pay great attention to the group of pregnant women infectedwith COVID-19.19,20Our review suggests that the most frequent abnormalities are elevated D-dimer (82%), elevated neutrophil count (81%), elevated C-reactive protein (69%), and decreased lymphocyte count (59%). However, a meta-analysis of adult COVID-19 infection reported that

Laboratory Abnormalities in Pregnant Women with Novel Coronavirus Disease 2019