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Blood samples from patients with coagulation disorders in obstetrics and with advanced carcinoma of the kidney were examined for the presence of cross-linked fibrinoligomers. Quantitative gel filtration of ß-alanine precipitated plasma samples and chain characterization of isolated fibrin derivatives by SDS-PAA gel electrophoresis after reduction with mercaptoethanol were performed. Electrophoresis of immunoadsorbed material was additionally applied. In all cases of intravascular coagulation crosslinked fibrinoligomers in amounts of 8-25 per cent of the total fibrinogen content were observed. Severe cases revealed a molecular weight pattern of derivatives ranging from 5 million and more down to 45 000. X, Y, D, E and D-dimer were found in the ß-alanine supernatant. In 5 patients with advanced renal carcinoma a cross-linked dimeric derivative was observed predominantly.  In vitro produced crosslinked 125 I-fibrinoligomers were injected into rabbits. Radioactivity was measured in gel filtrated fractions from ß-alanine precipitated samples, and a half-life time of approximately 7 hours of the high molecular weight fraction averaging 5 million daltons was found.  It is concluded that circulating crosslinked fibrinoligomers which differ in regard to complex formation and half-life time to soluble fibrin monomer complexes may indicate intravascular coagulation.

Circulating Crosslinked Fibrinoligomers. Clinical Observations and Turnover Studies in Rabbits