English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Plus annual

Presents the access of premium content as premium feature

Premium Content

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools annual

Global: Zendy Free Plan

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Using high power Nomarski optics the film presents the shape change of thrombocytes in vitro. Their native shape can be studied by immediate fixation of blood at venepuncture. Platelets appear as flat discs. Less than 25% show pseudopodes. In citrate blood and PRP a pro-qressing shape change occurs depending on time after blood sampling and on incubation temperature. Platelets tend to swell and tentacle formation continues with time. At room temperature 90% of thrombocytes have undergone these changes within 60 min. The addition of ADP (10-6 molar) to PRP induces the formation and rupture of large vesicles in single platelets. Thrombocytes are aggregating, many of the aggregated platelets show the same large vesicles. They are bursting and the release of a granular material can be observed. The remaining platelet material is fusing to an unstructured mass. Bencyclan (2 × 10-4 molar) affects platelet morphology by inducing a spherical transformation, which is paralleled by the inhibition of platelet adhesiveness, spreading and aggregation. Finally a platelet is shown spreading on a glass surface. The mor-nhologic changes of single platelets (primary shape change) demonstrated in the film probably represent basic processes in hemostasis and thrombus formation.

Morphologic Platelet Changes in Citrate Blood and PRP