English (United Kingdom)

https://curated-unify.zendy.io/wp-json/zendy-region/v1/featured_content/oa?rat=en

https://curated-unify.zendy.io/wp-json/zendy-region/v1/highlighted_journal/

Global: Zendy Tools annual

Presents the keyphrase highlighting as premium feature

Keyphrase Highlighting

Presents the summarisation as premium feature

Summarisation

Insights

Presents the pdf analysis as premium feature

PDF Analysis

Presents the zaia usage as premium feature

ZAIA

Global: Zendy Tools monthly

Global: Zendy Plus monthly

Presents the access of premium content as premium feature

Premium Content

Global: Zendy Plus annual

Global: Zendy Free Plan

Activated charcoal hemoperfusion is used for drug overdosage and is potentially useful in acute hepatic failure and chronic uremia. While hemocompatibility of early devices has improved, platelet loss still occurs, and may be associated with hemorrhage.  We have developed an in vitro circuit consisting of hemoperfusion column and lines with a total blood volume of 60 ml for use with human blood. Citrated whole blood hemoperfusion is associated with platelet depletion of similar magnitude for coated or uncoated charcoal (20%) whereas polymer coating of charcoal improved the profound platelet loss (90%) noted with perfusion of heparinized whole blood (3 U/ml) over uncoated charcoal.  At 14 day intervals, in a double blind cross over study, we compared the effects of 2 days treatment with aspirin (ASA)(600 mg/day) or sulfinpyrazone (SP)(800 mg/day) alone or in combination against placebo, on platelet adsorption on 2% hydrogel coated or uncoated charcoal, and platelet retention on cuprophan membranes PT150 and PT250 in a test cell system, in 8 healthy male volunteers. Bleeding time was also measured before and after treatment using a spring loaded device.  In a heparinized system, ASA, SP, and combination reduced mean platelet adsorption on coated charcoal from 53% to 41%, and mean platelet retention to membranes from 20% to 10%, whereas ASA alone reduced platelet adsorption on uncoated charcoal. Bleeding time,was prolonged by ASA but not by SP. These agents are capable of modifying platelet loss in vitro and may do so in vivo.

Effect of Sulfinpyrazone and Aspirin on Platelet Loss Induced In Vitro by Activated Charcoal Hemoperfusion