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Several methods have been proposed for the determination of platelet life-span. Among them the technique described by Stuart and al (l) based upon the ex-vivo assay of platelet malondialdehyde after one single oral intake of acetylsalicylic acid is receiving an increasing interest. We adapted this method for semi-automated determinations using an AutoAnalyzer system.  Platelet survival time was determined with this technique in healthy volunteers as well as in patients with abnormal platelet life-span.  In some instances chromium-51-determinations were also performed in order to assess the reliability of the method proposed. The results obtained are comparable for both methods and compatible with those described in the literature.

Nonradioactive Semi-Automated Determination of Platelet Survival Time in Man