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A patient developed severe thrombocytopenia and acute arterial occlusion 6 days after onset of heparin therapy. Heparin was ad ministered because of venous thrombosis in the lower limbs. Aggregometry showed the typical signes of heparin-induced thrombocytopenia with all evaluated heparins of different origin. PGI2 stimulating activity of plasma was in the range of normal plasma samples. No aggregating activity of the plasma could be shown without heparin(Method of Lian et al.). Heparin activity was determined before and after aggregation with a chromogenic substrate.  After cessation of heparin therapy the platelets raised into the lower normal range within a few days.

Arterial Thrombosis In Heparin-Induced Thrombo Cytopenia Is Not Accompanied By A Decreased PGI2 Stimulating Activity In Plasma