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The aim of the investigation was to compare the activity of factor XIII in patients with malignant neoplasma with the changes in the blood plasma of rats with Guering epitheliomas and to evaluate the effects of this tumour on the activity of tissue transamidase capable of stabilizing fibrin.  The investigations were carried out on 125 patients with several neoplasmas and 50 healthy subjects. A significant decrease in f. XIII activity in plasma was found in these patients, as well as decrease in the concentration of free SH groups on which its activity depends. Similar changes In the blood plasma were noted in rats examined 30 days after transplantation of the Guerin tumor. In the organs of these rats a fall in transamidase activity was observed. On the other hand the tumor rich in SH groups contains a very large amount of enzyme which like f. XIII is capable converting fibrin polimer into cross-linking fibrin. Concentration of this transamidase in neoplastic tissue was significant higher than in the tissue of the control animals.  Our results suggest that activity of transamidase and SH groups are connected with neoplastic process and that decrease of f. XIII activity in the blood plasma is the result of its consumption during intravascular coagulation initiated by neoplasma.

Factor XIII, Tissue Transamidase And Malignancy