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Serial serum myoglobin (SMb) and CK were determined m 20 patients with angiographically proven acute myocardial infarction due to acute occlusion of a major coronary artery branch. In 10 patienus treated medically SMb nealied 10 hours before CK, both peal: values and total release correlated with percent akinetic segment in the chronic stage. 10 patients had effective revascularisation by intracoronary application of streptokinase. Here CK and SMb peaked earlier with SMb reaching its maximum 6.5 hours before CK; both maxima were higher than in the conservatively treated group. There was no linear correlation between CK and SMb oeak or CK and SMb release and extent of akinetic area indicating an improved wash-out from the infarcted area. Interrelations between jeopardized area reperfusion time and delay, and myoglobin release are discussed. In all these cases SMb seems to be the best biochemical parameter indicating successfull reopening of acute occluded coronary arteries by intracoronary thrombolysis wi th streptokinase.

Serum Myoglobin In Acute Myocardial Infarction: Conservative Treatment Versus Acute Revascularisation By Intbacoronaby Streptokinase